منابع مشابه
Self-Digestion ofIluman Erythrocyte Membranes
Sialic acid residues are responsible for the negative charge at the cell surface in human erythrocytes (Eylar et al., 1962), and are involved in Mand N-group specificity (Ebert & Jurgen, 1972). The sialic acid content decreases as erythrocytes age (Balduini et al., 1974; Baxter & Beeley, 1975), and its role as a determinant of the erythrocyte lifespan is described in several reports (Jancik & S...
متن کاملMultiscale simulation of erythrocyte membranes.
To quantitatively predict the mechanical response and mechanically induced remodeling of red blood cells, we developed a multiscale method to correlate distributions of internal stress with overall cell deformation. This method consists of three models at different length scales: in the complete cell level the membrane is modeled as two distinct layers of continuum shells using finite element m...
متن کاملCalmodulin Interactions with Erythrocyte Membranes
Two new vascular smooth muscle relaxants, bepridil and cetiedil, were found to possess specific CaM-inhibitory properties which resembled those of trifluoperazine. Trifluoperazine, bepridil, and cetiedil inhibited Ca2+-dependent '251-CaM binding to erythrocyte membranes and CaM activation of membrane Ca2+-ATPase with IC50 values of -12, 17, and -40 MAM, respectively. This does not appear to be ...
متن کاملComparison of hemoglobin Köln erythrocyte membranes with malondialdehyde-reacted normal erythrocyte membranes.
Splenectomized patients with hemoglobin (Hb) Köln have rigid RBCs with membrane polypeptide aggregates that are not dissociable with disulfide-reducing agents. Malondialdehyde (MDA) action on normal RBCs produced rigid RBCs with similar nondissociable aggregates. To test the hypothesis that Hb Köln RBC aggregates contained unsaturated MDA-type bonds, we reduced normal control RBC membranes, Hb ...
متن کاملAdriamycin induces protein oxidation in erythrocyte membranes.
Adriamycin is an anthracycline antineoplastic agent whose clinical effectiveness is limited by severe side effects, including cardiotoxicity. A current hypothesis for adriamycin cardiotoxicity involves free radical oxidative stress. To investigate this hypothesis in a model system, we applied the technique of immunochemical detection of protein carbonyls, known to be increased in oxidized prote...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1982
ISSN: 0021-9746
DOI: 10.1136/jcp.35.7.795-d